Functional & Conserved Residues
The ConSurf server is a useful and user-friendly tool that enables the identification of functionally important regions on the surface of a protein or domain, of known three-dimensional (3D) structure, based on the phylogenetic relations between its close sequence homologues.
http://consurf.tau.ac.il/
Crescendo can only be used to identify residues that are interacting with ligands or other proteins.
http://mordred.bioc.cam.ac.uk/~crescendo/crescendo.php
3dLOGO is a web server that allows the identification of 3D locally conserved residues in a set of protein structures.
http://3dlogo.uniroma2.it/3dLOGO/index.html
Firestar predicts functionally important residues from structural templates and alignment reliability.
http://firedb.bioinfo.cnio.es/Php/FireStar.php
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