Proteins are indispensable players in virtually all biological events.
The functions of proteins are coordinated through intricate regulatory
networks of transient protein-protein interactions (PPIs). To predict
and/or study PPIs, a wide variety of techniques have been developed over
the last several decades. Many in vitro and in vivo assays have been
implemented to explore the mechanism of these ubiquitous interactions.
However, despite significant advances in these experimental approaches,
many limitations exist such as false-positives/false-negatives,
difficulty in obtaining crystal structures of proteins, challenges in
the detection of transient PPI, among others. To overcome these
limitations, many computational approaches have been developed which are
becoming increasingly widely used to facilitate the investigation of
PPIs. This book has gathered an ensemble of experts in the field, in 22
chapters, which have been broadly categorized into Computational
Approaches, Experimental Approaches, and Others.
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